PHARMACOKINETICS OF WELTRUZA

WELTRUZA is a [new] once-monthly subcutaneous long-acting injectable formulation of olanzapine.1

Pharmacokinetics: Simulated Steady-State Plasma Concentration2,3

Simulated Plasma Concentration Over Time in Patient Populations Treated with WELTRUZA and Oral Olanzapine During the First Day of Treatment2

Plasma Concentration graph

WELTRUZA reaches levels comparable with oral olanzapine on first day of treatment.2

Simulated Steady-State Plasma Concentration–Time Profiles for WELTRUZA Versus Corresponding Oral Olanzapine Doses3

Pharmacokinetics chart

References: 1. WELTRUZA™ (olanzapine) extended-release injectable suspension Current Prescribing Information. Parsippany, NJ: Teva Neuroscience, Inc. 2. Data on file. Summary of Clinical Pharmacology Studies. June 2026. Parsippany, NJ: Teva Neuroscience, Inc. 3. Patel N, Schmidt H, Perlstein I, Merenlender-Wagner A, Elgart A, Singh R. Joint population pharmacokinetic model of olanzapine following oral, intramuscular, and subcutaneous (TV-44749) administration to support TV-44749 dose recommendations and switching strategies. Presented at: Schizophrenia International Research Society (SIRS) 2025 Annual Congress; March 25-March 29, 2026; Florence, Italy.